MLB Predictions - MLBGameSim.com

MLB Predictions for 5/16/2025


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Odds: Line |  O/U |  Money Line
Time *ETMatchupPredictionActualResult
2:20 PM Chicago White Sox @ Chicago Cubs  
Shane Smith vs Cade Horton
by 1.5
+/- Lineups
Chicago Cubs win 5.0-3.3
  by 1.7
Chicago Cubs wins 13-3
 
5:10 PM Cleveland Guardians @ Cincinnati Reds  
Tanner Bibee vs Brady Singer
by 1.5
+/- Lineups
Cleveland Guardians win 4.9-3.8
  by 1.1
Cincinnati Reds wins 5-4
 
6:45 PM Pittsburgh Pirates @ Philadelphia Phillies  
Andrew Heaney vs Ranger Suarez
by 1.5
+/- Lineups
Philadelphia Phillies win 4.7-3.4
  by 1.3
Philadelphia Phillies wins 8-4
7:05 PM Washington Nationals @ Baltimore Orioles  
MacKenzie Gore vs Cade Povich
by 1.5
+/- Lineups
Washington Nationals win 4.2-3.4
  by 0.7
Washington Nationals wins 4-3
  
7:05 PM New York Mets @ New York Yankees  
Tylor Megill vs Carlos Rodon
by 1.5
+/- Lineups
New York Yankees win 4.5-3.4
  by 1.0
New York Yankees wins 6-2
7:07 PM Detroit Tigers @ Toronto Blue Jays  
Jack Flaherty vs Bowden Francis
by 1.5
+/- Lineups
Detroit Tigers win 5.2-4.5
  by 0.7
Detroit Tigers wins 5-4
  
7:10 PM Atlanta Braves @ Boston Red Sox  
Chris Sale vs Garrett Crochet
by 1.5
+/- Lineups
Boston Red Sox win 4.7-3.1
  by 1.6
Atlanta Braves wins 4-2
7:10 PM Tampa Bay Rays @ Miami Marlins  
Taj Bradley vs Max Meyer
by 1.5
+/- Lineups
Miami Marlins win 3.9-3.7
  by 0.2
Miami Marlins wins 9-4
 
7:40 PM St. Louis Cardinals @ Kansas City Royals  
Andre Pallante vs Cole Ragans
by 1.5
+/- Lineups
St. Louis Cardinals win 4.6-4.3
  by 0.3
St. Louis Cardinals wins 10-3
 
8:05 PM Houston Astros @ Texas Rangers  
Lance McCullers vs Nathan Eovaldi
by 1.5
+/- Lineups
Houston Astros win 3.2-3.1
  by 0.1
Houston Astros wins 6-3
 
8:10 PM Minnesota Twins @ Milwaukee Brewers  
Joe Ryan vs Chad Patrick
by 1.5
+/- Lineups
Milwaukee Brewers win 3.6-2.9
  by 0.7
Minnesota Twins wins 3-0
9:40 PM Colorado Rockies @ Arizona Diamondbacks  
Carson Palmquist vs Corbin Burnes
by 1.5
+/- Lineups
Arizona Diamondbacks win 5.0-3.6
  by 1.4
Arizona Diamondbacks wins 8-0
9:40 PM Seattle Mariners @ San Diego Padres  
Logan Evans vs Stephen Kolek
by 1.5
+/- Lineups
San Diego Padres win 6.2-4.3
  by 2.0
Seattle Mariners wins 5-1
10:10 PM Los Angeles Angels @ Los Angeles Dodgers  
Jack Kochanowicz vs Dustin May
by 1.5
+/- Lineups
Los Angeles Dodgers win 5.4-3.9
  by 1.5
Los Angeles Angels wins 6-2
 
10:15 PM Athletics @ San Francisco Giants  
JP Sears vs Logan Webb
by 1.5
+/- Lineups
Athletics win 4.9-3.8
  by 1.1
San Francisco Giants wins 9-1

Legend/Totals

Correct Picks 9 (60.0%)
Incorrect Picks 6 (40.0%)
Final Margin within 5 Pts 2 (13.3%)
Beat the Spread 8 (53.3%)
         
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