MLB Predictions - MLBGameSim.com

MLB Predictions for 5/21/2025


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Odds: Line |  O/U |  Money Line
Time *ETMatchupPredictionActualResult
12:35 PM Cincinnati Reds @ Pittsburgh Pirates  
Brady Singer vs Andrew Heaney
by 1.5
+/- Lineups
Cincinnati Reds win 3.2-3.2
  by 0.0
Pittsburgh Pirates wins 3-1
 
1:10 PM Cleveland Guardians @ Minnesota Twins  
Logan Allen vs Bailey Ober
by 1.5
+/- Lineups
Cleveland Guardians win 3.4-2.5
  by 0.8
Minnesota Twins wins 6-5
 
1:10 PM Houston Astros @ Tampa Bay Rays  
Hunter Brown vs Taj Bradley
by 1.5
+/- Lineups
Houston Astros win 4.0-2.8
  by 1.2
Tampa Bay Rays wins 8-4
 
1:10 PM Chicago Cubs @ Miami Marlins  
Cade Horton vs Max Meyer
by 1.5
+/- Lineups
Chicago Cubs win 4.5-4.5
  by 0.0
Chicago Cubs wins 2-1
  
1:10 PM Baltimore Orioles @ Milwaukee Brewers  
Tomoyuki Sugano vs Chad Patrick
by 1.5
+/- Lineups
Baltimore Orioles win 4.5-3.7
  by 0.8
Baltimore Orioles wins 8-4
1:15 PM Detroit Tigers @ St. Louis Cardinals  
Brant Hurter vs Andre Pallante
by 1.5
+/- Lineups
Detroit Tigers win 4.5-3.8
  by 0.7
Detroit Tigers wins 5-1
2:10 PM Seattle Mariners @ Chicago White Sox  
Logan Evans vs Shane Smith
by 1.5
+/- Lineups
Seattle Mariners win 4.2-3.9
  by 0.4
Seattle Mariners wins 6-5
  
3:45 PM Kansas City Royals @ San Francisco Giants  
Daniel Lynch vs Logan Webb
by 1.5
+/- Lineups
San Francisco Giants win 3.4-3.2
  by 0.1
Kansas City Royals wins 8-4
 
3:55 PM Cleveland Guardians @ Minnesota Twins  
Gavin Williams vs Chris Paddack
by 1.5
+/- Lineups
Cleveland Guardians win 3.7-3.6
  by 0.1
Cleveland Guardians wins 5-1
6:45 PM New York Mets @ Boston Red Sox  
Tylor Megill vs Garrett Crochet
by 1.5
+/- Lineups
Boston Red Sox win 3.4-2.9
  by 0.5
New York Mets wins 5-1
 
6:45 PM Atlanta Braves @ Washington Nationals  
AJ Smith-Shawver vs Trevor Williams
by 1.5
+/- Lineups
Atlanta Braves win 4.6-3.8
  by 0.7
Simulate
Postponed
 
7:05 PM Texas Rangers @ New York Yankees  
Jacob deGrom vs Ryan Yarbrough
by 1.5
+/- Lineups
New York Yankees win 3.7-2.9
  by 0.7
New York Yankees wins 4-3
  
7:07 PM San Diego Padres @ Toronto Blue Jays  
Randy Vasquez vs Kevin Gausman
by 1.5
+/- Lineups
San Diego Padres win 4.1-3.9
  by 0.1
Toronto Blue Jays wins 14-0
8:40 PM Philadelphia Phillies @ Colorado Rockies  
Taijuan Walker vs Carson Palmquist
by 1.5
+/- Lineups
Philadelphia Phillies win 3.9-3.3
  by 0.6
Philadelphia Phillies wins 9-5
10:05 PM Los Angeles Angels @ Athletics  
Jack Kochanowicz vs JP Sears
by 1.5
+/- Lineups
Athletics win 5.1-3.1
  by 2.0
Los Angeles Angels wins 10-5
10:10 PM Arizona Diamondbacks @ Los Angeles Dodgers  
Corbin Burnes vs Dustin May
by 1.5
+/- Lineups
Arizona Diamondbacks win 6.0-5.1
  by 1.0
Los Angeles Dodgers wins 3-1

Legend/Totals

Correct Picks 7 (46.7%)
Incorrect Picks 8 (53.3%)
Final Margin within 5 Pts 3 (20.0%)
Beat the Spread 8 (53.3%)
         
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