MLB Predictions - MLBGameSim.com

MLB Predictions for 6/21/2025


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Odds: Line |  O/U |  Money Line
Time *ETMatchupPredictionActualResult
12:10 PM Detroit Tigers @ Tampa Bay Rays  
Sawyer Gipson-Long vs Ryan Pepiot
by 1.5
+/- Lineups
Detroit Tigers win 4.4-4.2
  by 0.2
Tampa Bay Rays wins 8-3
1:05 PM Baltimore Orioles @ New York Yankees  
Zach Eflin vs Clarke Schmidt
by 1.5
+/- Lineups
New York Yankees win 6.0-4.9
  by 1.0
New York Yankees wins 9-0
2:10 PM Milwaukee Brewers @ Minnesota Twins  
Jose Quintana vs Simeon Woods Richardson
by 1.5
+/- Lineups
Minnesota Twins win 5.6-5.1
  by 0.5
Milwaukee Brewers wins 9-0
 
2:15 PM Cincinnati Reds @ St. Louis Cardinals  
Chase Petty vs Sonny Gray
by 1.5
+/- Lineups
Cincinnati Reds win 5.9-5.7
  by 0.2
St. Louis Cardinals wins 6-5
 
2:20 PM Seattle Mariners @ Chicago Cubs  
Emerson Hancock vs Cade Horton
by 1.5
+/- Lineups
Chicago Cubs win 7.0-6.5
  by 0.5
Chicago Cubs wins 10-7
3:07 PM Chicago White Sox @ Toronto Blue Jays  
Aaron Civale vs Jose Berrios
by 1.5
+/- Lineups
Toronto Blue Jays win 4.5-3.0
  by 1.6
Toronto Blue Jays wins 7-1
 
4:05 PM Texas Rangers @ Pittsburgh Pirates  
Kumar Rocker vs Mitch Keller
by 1.5
+/- Lineups
Pittsburgh Pirates win 4.6-3.9
  by 0.7
Texas Rangers wins 3-2
 
4:05 PM Boston Red Sox @ San Francisco Giants  
Brayan Bello vs Landen Roupp
by 1.5
+/- Lineups
San Francisco Giants win 5.0-4.4
  by 0.6
San Francisco Giants wins 3-2
  
4:10 PM Atlanta Braves @ Miami Marlins  
Grant Holmes vs Eury Perez
by 1.5
+/- Lineups
Atlanta Braves win 5.0-3.8
  by 1.2
Atlanta Braves wins 7-0
7:15 PM Kansas City Royals @ San Diego Padres  
Noah Cameron vs Dylan Cease
by 1.5
+/- Lineups
Kansas City Royals win 3.9-3.4
  by 0.5
San Diego Padres wins 5-1
7:15 PM New York Mets @ Philadelphia Phillies  
Griffin Canning vs Mick Abel
by 1.5
+/- Lineups
New York Mets win 5.7-4.4
  by 1.3
New York Mets wins 11-4
9:10 PM Arizona Diamondbacks @ Colorado Rockies  
Merrill Kelly vs Carson Palmquist
by 1.5
+/- Lineups
Arizona Diamondbacks win 7.2-5.2
  by 2.0
Arizona Diamondbacks wins 5-3
  
9:38 PM Houston Astros @ Los Angeles Angels  
Brandon Walter vs Jose Soriano
by 1.5
+/- Lineups
Houston Astros win 4.8-3.5
  by 1.3
Los Angeles Angels wins 9-1
10:05 PM Cleveland Guardians @ Athletics  
Luis Ortiz vs Mitch Spence
by 1.5
+/- Lineups
Athletics win 4.7-4.2
  by 0.5
Cleveland Guardians wins 4-2
10:10 PM Washington Nationals @ Los Angeles Dodgers  
Jake Irvin vs Dustin May
by 1.5
+/- Lineups
Los Angeles Dodgers win 5.3-4.1
  by 1.2
Washington Nationals wins 7-3
 

Legend/Totals

Correct Picks 7 (46.7%)
Incorrect Picks 8 (53.3%)
Final Margin within 5 Pts 2 (13.3%)
Beat the Spread 7 (46.7%)
         
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