MLB Predictions - MLBGameSim.com

MLB Predictions for 7/21/2025

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Odds: Line | O/U | Money Line

Time *ET	Matchup	Prediction	Actual	Result
6:40 PM	Baltimore Orioles @ Cleveland Guardians Tomoyuki Sugano vs Tanner Bibee -143 or 58.8% +/- Lineups Jackson Holliday 2B Jordan Westburg 3B Gunnar Henderson SS Ryan O'Hearn 1B Ramon Laureano LF Colton Cowser DH Tyler O'Neill RF Cedric Mullins CF Alex Jackson C Tomoyuki Sugano P Steven Kwan LF Angel Martinez CF Jose Ramirez 3B Kyle Manzardo DH Carlos Santana 1B Nolan Jones RF Daniel Schneemann 2B Brayan Rocchio SS Bo Naylor C Tanner Bibee P	Cleveland Guardians win 51.0% of sims by 0.4	Cleveland Guardians wins 10-5
6:40 PM	Detroit Tigers @ Pittsburgh Pirates Jack Flaherty vs Paul Skenes -135 or 57.4% +/- Lineups Colt Keith 3B Gleyber Torres 2B Riley Greene DH Spencer Torkelson 1B Zach McKinstry RF Dillon Dingler C Parker Meadows CF Matt Vierling LF Trey Sweeney SS Jack Flaherty P Spencer Horwitz 1B Andrew McCutchen DH Bryan Reynolds RF Nick Gonzales 2B Oneil Cruz CF Ke'Bryan Hayes 3B Jack Suwinski LF Henry Davis C Isiah Kiner-Falefa SS Paul Skenes P	Pittsburgh Pirates win 51.9% of sims by 0.2	Pittsburgh Pirates wins 3-0
6:40 PM	San Diego Padres @ Miami Marlins Randy Vasquez vs Eury Perez -142 or 58.7% +/- Lineups Fernando Tatis RF Luis Arraez 1B Manny Machado 3B Gavin Sheets LF Xander Bogaerts SS Jackson Merrill CF Jake Cronenworth DH Jose Iglesias 2B Martin Maldonado C Randy Vasquez P Xavier Edwards 2B Jesus Sanchez RF Otto Lopez SS Agustin Ramirez C Kyle Stowers LF Liam Hicks 1B Heriberto Hernandez DH Graham Pauley 3B Dane Myers CF Eury Perez P	Miami Marlins win 65.1% of sims by 1.3	San Diego Padres wins 2-1
6:45 PM	Cincinnati Reds @ Washington Nationals Brady Singer vs Jake Irvin -104 or 51.0% +/- Lineups TJ Friedl CF Matt McLain 2B Elly De La Cruz SS Austin Hays LF Gavin Lux DH Spencer Steer 1B Noelvi Marte 3B Jake Fraley RF Jose Trevino C Brady Singer P CJ Abrams SS James Wood LF Josh Bell DH Nathaniel Lowe 1B Brady House 3B Daylen Lile RF Amed Rosario 2B Riley Adams C Jacob Young CF Jake Irvin P	Cincinnati Reds win 55.4% of sims by 0.9	Washington Nationals wins 10-8
6:45 PM	Boston Red Sox @ Philadelphia Phillies Walker Buehler vs Zack Wheeler -245 or 71.0% +/- Lineups Jarren Duran LF Alex Bregman 3B Roman Anthony DH Trevor Story SS Wilyer Abreu RF Ceddanne Rafaela CF Marcelo Mayer 2B Carlos Narvaez C Abraham Toro 1B Walker Buehler P Trea Turner SS Kyle Schwarber DH Bryce Harper 1B Nick Castellanos RF J.T. Realmuto C Brandon Marsh CF Otto Kemp 3B Max Kepler LF Bryson Stott 2B Zack Wheeler P	Philadelphia Phillies win 61.8% of sims by 1.2	Philadelphia Phillies wins 3-2
7:07 PM	New York Yankees @ Toronto Blue Jays Carlos Rodon vs Kevin Gausman -100 or 50.0% +/- Lineups Trent Grisham CF Aaron Judge RF Jazz Chisholm 2B Giancarlo Stanton DH Jasson Dominguez LF Paul Goldschmidt 1B Austin Wells C Anthony Volpe SS Oswald Peraza 3B Carlos Rodon P Ernie Clement 3B George Springer DH Vladimir Guerrero 1B Bo Bichette SS Alejandro Kirk C Davis Schneider LF Myles Straw CF Leo Jimenez 2B Joey Loperfido RF Kevin Gausman P	New York Yankees win 55.9% of sims by 0.9	Toronto Blue Jays wins 4-1
7:10 PM	Los Angeles Angels @ New York Mets Tyler Anderson vs Kodai Senga -190 or 65.5% +/- Lineups Zach Neto SS Nolan Schanuel 1B Mike Trout DH Taylor Ward LF Jo Adell CF Yoan Moncada 3B Logan O'Hoppe C LaMonte Wade RF Luis Rengifo 2B Tyler Anderson P Brandon Nimmo LF Francisco Lindor SS Juan Soto RF Pete Alonso 1B Jeff McNeil CF Mark Vientos DH Brett Baty 3B Francisco Alvarez C Luisangel Acuna 2B Kodai Senga P	Los Angeles Angels win 50.9% of sims by 0.4	New York Mets wins 7-5
7:15 PM	San Francisco Giants @ Atlanta Braves Hayden Birdsong vs Bryce Elder -134 or 57.3% +/- Lineups Jung Hoo Lee CF Heliot Ramos LF Rafael Devers DH Willy Adames SS Matt Chapman 3B Mike Yastrzemski RF Wilmer Flores 1B Casey Schmitt 2B Patrick Bailey C Hayden Birdsong P Jurickson Profar LF Matt Olson 1B Ronald Acuna RF Drake Baldwin DH Ozzie Albies 2B Sean Murphy C Nacho Alvarez 3B Michael Harris CF Nick Allen SS Bryce Elder P	San Francisco Giants win 53.8% of sims by 0.8	Atlanta Braves wins 9-5
7:35 PM	Chicago White Sox @ Tampa Bay Rays Sean Burke vs Shane Baz -218 or 68.6% +/- Lineups Mike Tauchman RF Chase Meidroth SS Andrew Benintendi DH Miguel Vargas 1B Kyle Teel C Luis Robert CF Colson Montgomery 3B Lenyn Sosa 2B Brooks Baldwin LF Sean Burke P Chandler Simpson CF Yandy Diaz DH Jonathan Aranda 1B Junior Caminero 3B Josh Lowe RF Ha-Seong Kim SS Christopher Morel LF Danny Jansen C Taylor Walls 2B Shane Baz P	Tampa Bay Rays win 55.6% of sims by 0.4	Chicago White Sox wins 8-3
8:05 PM	Kansas City Royals @ Chicago Cubs Noah Cameron vs Ben Brown -154 or 60.6% +/- Lineups Jonathan India DH Bobby Witt SS Vinnie Pasquantino 1B Maikel Garcia 3B Salvador Perez C Jac Caglianone RF Nick Loftin 2B John Rave LF Kyle Isbel CF Noah Cameron P Nico Hoerner 2B Kyle Tucker RF Seiya Suzuki CF Carson Kelly C Ian Happ LF Dansby Swanson SS Michael Busch 1B Justin Turner DH Matt Shaw 3B Ben Brown P	Chicago Cubs win 55.2% of sims by 0.2	Kansas City Royals wins 12-4
8:05 PM	Athletics @ Texas Rangers Jacob Lopez vs Jack Leiter -125 or 55.6% +/- Lineups Lawrence Butler CF Jacob Wilson SS Nick Kurtz 1B Brent Rooker DH Shea Langeliers C Tyler Soderstrom LF Miguel Andujar RF Max Muncy 3B Luis Urias 2B Jacob Lopez P Michael Helman CF Corey Seager SS Marcus Semien 2B Adolis Garcia RF Wyatt Langford LF Kyle Higashioka C Josh Smith 1B Josh Jung 3B Cody Freeman DH Jack Leiter P	Athletics win 59.2% of sims by 1.1	Texas Rangers wins 7-2
8:40 PM	St. Louis Cardinals @ Colorado Rockies Michael McGreevy vs Austin Gomber -148 or 59.7% +/- Lineups Brendan Donovan 2B Ivan Herrera DH Willson Contreras 1B Alec Burleson LF Nolan Arenado 3B Masyn Winn SS Jordan Walker RF Pedro Pages C Victor Scott CF Michael McGreevy P Mickey Moniak RF Ezequiel Tovar SS Hunter Goodman C Jordan Beck LF Ryan McMahon 3B Brenton Doyle CF Yanquiel Fernandez DH Orlando Arcia 1B Adael Amador 2B Austin Gomber P	St. Louis Cardinals win 54.9% of sims by 0.7	St. Louis Cardinals wins 6-2
9:40 PM	Houston Astros @ Arizona Diamondbacks Colton Gordon vs Zac Gallen -142 or 58.7% +/- Lineups Cam Smith RF Jose Altuve DH Victor Caratini C Christian Walker 1B Taylor Trammell LF Mauricio Dubon 3B Chas McCormick CF Brice Matthews 2B Zack Short SS Colton Gordon P Ketel Marte DH Corbin Carroll CF Lourdes Gurriel LF Eugenio Suarez 3B Josh Naylor 1B Randal Grichuk RF James McCann C Blaze Alexander 2B Geraldo Perdomo SS Zac Gallen P	Arizona Diamondbacks win 71.5% of sims by 1.8	Houston Astros wins 6-3
9:40 PM	Milwaukee Brewers @ Seattle Mariners Brandon Woodruff vs George Kirby -130 or 56.5% +/- Lineups Brice Turang 2B William Contreras C Christian Yelich DH Jackson Chourio RF Isaac Collins LF Andrew Vaughn 1B Blake Perkins CF Anthony Seigler 3B Joey Ortiz SS Brandon Woodruff P J.P. Crawford SS Julio Rodriguez CF Cal Raleigh C Randy Arozarena LF Jorge Polanco DH Luke Raley 1B Dominic Canzone RF Ben Williamson 3B Cole Young 2B George Kirby P	Seattle Mariners win 62.5% of sims by 1.1	Milwaukee Brewers wins 6-0
10:10 PM	Minnesota Twins @ Los Angeles Dodgers David Festa vs Dustin May -181 or 64.4% +/- Lineups Byron Buxton CF Willi Castro 2B Trevor Larnach DH Ryan Jeffers C Kody Clemens 1B Carlos Correa SS Royce Lewis 3B Matt Wallner RF Harrison Bader LF David Festa P Mookie Betts SS Shohei Ohtani DH Will Smith C Freddie Freeman 1B Teoscar Hernandez RF Michael Conforto LF Andy Pages CF Hyeseong Kim 2B Tommy Edman 3B Dustin May P	Los Angeles Dodgers win 56.6% of sims by 0.4	Los Angeles Dodgers wins 5-2

Legend/Totals

Correct Picks	3 (20.0%)
Incorrect Picks	12 (80.0%)
Final Margin within 5 Pts	1 (6.7%)
Beat the Spread	2 (13.3%)

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